Valproate - A Standard Drug with a Broad Spectrum of Indications
Valproate exhibits e.g. anticonvulsant, mood-stabilizing and antimanic activities; it has also shown tumor inhibitory effects in clinical studies. It is not only effective for all forms of epilepsy but also still represents the gold standard for primary generalized seizures, as has been impressively demonstrated in recent studies.
Thus, Valproate is a proven classic medication, its broad spectrum of indications ensuring its firm position in the future as well. This booklet written by Günther Krämer M.D., medical director of the Swiss Epilepsy Center in Zurich, presents a comprehensive and most up-to-date overview of the treatment with Valproate, see table of contents.
This 64-page paperback will be available free of charge. You can ask your local Desitin representative for a copy from July 2010 onwards.
Table of Contents
5 Foreword
6 Chemistry and Pharmacology of Valproate
6 Chemistry
6 Activity
7 Pharmacokinetics
12 Valproate in Epilepsy
13 Early Studies with Valproate
13 Idiopathic Epilepsies with Primary Generalized Seizures and Symptomatic Epilepsies with Generalized Seizures
16 Symptomatic and Presumed Symptomatic (Cryptogenic) Epilepsies with Focal Seizures (with or without Secondary Generalization)
21 Add-On Therapy for Focal Epilepsies in Comparison toPlacebo
23 Add-On Therapy for Focal Epilepsies in Comparison to Other Antiepileptic Drugs
23 Cochrane Analysis
24 Valproate in Comparison to New Antiepileptic Drugs
24 Valproate versus Oxcarbazepine
24 Valproate versus Lamotrigine
25 Valproate versus Topiramate
25 Benefi t-Risk Profi le for Valproate in Focal Epilepsies
27 Valproate in Children
27 Valproate in Elderly Patients
28 Valproate for Status Epilepticus
